Synthesis of human growth hormone-releasing hormone via three-fragment serine/threonine ligation (STL).

Realizing serine/threonine ligation: scope and limitations and mechanistic implication thereof

Serine/Threonine ligation (STL) has emerged as an alternative tool for protein chemical synthesis, bioconjugations as well as macrocyclization of peptides of various sizes. Owning to the high abundance of Ser/Thr residues in natural peptides and proteins, STL is expected to find a wide range of applications in chemical biology research. Herein, we have fully investigated the compatibility of th...

Effective synthesis of kynurenine-containing peptides via on-resin ozonolysis of tryptophan residues: synthesis of cyclomontanin B.

The preparation of Kyn-containing peptides is difficult, owing to the low reactivity of Kyn in the coupling reaction. In this report, Kyn-containing peptides were efficiently obtained via on-resin ozonolysis of the corresponding Trp-containing peptide. In addition, a Kyn-containing cyclic peptide, cyclomontanin B, has been synthesized by this strategy in the combination with serine/threonine li...

Comparison of Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variant 1 in Different Stages of Endometriosis

The molecular mechanism of EGF receptor activation in pancreatic beta-cells by thyrotropin-releasing hormone.

Thyrotropin-releasing hormone (TRH) and its receptor subtype TRH receptor-1 (TRHR1) are found in pancreatic beta-cells, and it has been shown that TRH might have potential for autocrine/paracrine regulation through the TRHR1 receptor. In this paper, TRHR1 is studied to find whether it can initiate multiple signal transduction pathways to activate the epidermal growth factor (EGF) receptor in pa...

The molecular mechanism of EGF receptor activation in pancreatic -cells by thyrotropin-releasing hormone

Luo, LuGuang, Naohiro Yano, and John Z. Q. Luo. The molecular mechanism of EGF receptor activation in pancreatic -cells by thyrotropin-releasing hormone. Am J Physiol Endocrinol Metab 290: E889–E899, 2006; doi:10.1152/ajpendo.00466.2005.—Thyrotropin-releasing hormone (TRH) and its receptor subtype TRH receptor-1 (TRHR1) are found in pancreatic -cells, and it has been shown that TRH might have p...